In the era of the Fifth Industrial Revolution, leaders, innovators and pioneers design, generate, and shape future-proof organizations, driven by a meaningful purpose promoting social impacts, combining emerging technologies and new ways of collaborating and conceiving work. While the “why” is clear and quite declared by many, the “what” to do and the “how” to do it remain very nebulous and, in some cases, obscure. Those ones who lead innovation within an organization suffer the innovation paradox: must innovate without knowing what and how. Innovators and pioneers are often alone, without a framework and processes for an open innovation execution. How can we unlock and unleash innovation, ensuring that the actions taken are always driven by what is truly needed to evolve your organization?